H3B-6527

产品编号: DC10033 Featured
H3B-6527
结构式
1702259-66-2
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中国地区超过5000个高品质化合物库存
应用领域
H3B-6527是一个有选择性的FGFR4抑制剂,有抗肿瘤的性质。
Cas No.: 1702259-66-2
名称:
别名: H3B6527,H3B 6527
SMILES: C=CC(NC1=CC(N2CCN(CC)CC2)=CC=C1NC3=NC=NC(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C)=C3)=O
分子式: C29H34Cl2N8O4
分子量: 629.54
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10092 BLU554(Fisogatinib) Fisogatinib (BLU-554) 是一种有效的高选择性口服的 FGFR4 抑制剂,其 IC50 值为 5 nM。Fisogatinib 在依赖 FGFR4 信号传导的肝细胞癌 (HCC) 模型中具有显着的抗肿瘤活性。
DC10033 H3B-6527 H3B-6527是一个有选择性的FGFR4抑制剂,有抗肿瘤的性质。