C-DIM12
产品编号: DC9277
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应用领域
C-DIM12是一种人工合成的Nurr1激活剂, 诱导Nurr1和DA基因表达。
| Cas No.: |
178946-89-9 |
| 名称: |
1,1-bis(3-indolyl)-1-(p-chlorophenyl)methane |
| 别名: |
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| SMILES: |
ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
| 分子式: |
C23H17ClN2 |
| 分子量: |
356.11 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2606_DC9277_178946-89-9 |
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COA
| LOT NO. |
DOWNLOAD |
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