LXH254
产品编号: DC10828
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应用领域
LXH254 是一种有效的 B/C RAF 抑制剂，详细信息请参考专利文献 WO2018051306A1 中的化合物 A。
| Cas No.: |
1800398-38-2 |
| 名称: |
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| 别名: |
LXH254; LXH-254; LXH 254 |
| SMILES: |
CC1=CC=C(NC(C2=CC(C(F)(F)F)=NC=C2)=O)C=C1C3=CC(N4CCOCC4)=NC(OCCO)=C3 |
| 分子式: |
C25H25F3N4O4 |
| 分子量: |
502.49 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
LXH254 is an orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, pan-RAF inhibitor LXH254 binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival. |
| Kinase Assay: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_570_DC10828_1800398-38-2 |
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COA
| LOT NO. |
DOWNLOAD |
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