IRAK4-IN-1
产品编号: DC10584
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中国地区超过5000个高品质化合物库存
应用领域
IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂，IC50 为 7 nM。
| Cas No.: |
1820787-94-7 |
| 名称: |
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| 别名: |
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| SMILES: |
C1C[C@@H](NC2=C3C=C(C#N)C=CC3=NC=N2)CC[C@@H]1N1CCOCC1 |
| 分子式: |
C19H23N5O |
| 分子量: |
337.42 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
In Vitro:
The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB).
In Vivo：
Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance (Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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