KG-501(Naphthol AS-E phosphate)
产品编号: DC10654
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应用领域
KG-501 是 CREB 的抑制剂，其 IC50 值为 6.89 μM。
| Cas No.: |
18228-17-6 |
| 名称: |
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| 别名: |
N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide; KG-501; NASEP，Naphthol AS-E phosphate,KG501,KG 501 |
| SMILES: |
ClC(C=C1)=CC=C1NC(C2=CC3=CC=CC=C3C=C2OP(O)(O)=O)=O |
| 分子式: |
C17H13ClNO5P |
| 分子量: |
377.72 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1β-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_401_DC10654_18228-17-6 |
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COA
| LOT NO. |
DOWNLOAD |
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