Zibotentan(ZD4054)

产品编号: DC9435 Featured
Zibotentan(ZD4054)
结构式
186497-07-4
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中国地区超过5000个高品质化合物库存
应用领域
Zibotentan (ZD4054)是口服活性的内皮素A(ETA)受体特异性拮抗剂,IC50为21 nM。
Cas No.: 186497-07-4
名称:
别名: ZD4054;ZD-4054;ZD 4054
SMILES: CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4
分子式: C19H16N6O4S
分子量: 424.4331
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). Zibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC9435 Zibotentan(ZD4054) Zibotentan (ZD4054)是口服活性的内皮素A(ETA)受体特异性拮抗剂,IC50为21 nM。