NCT-503
产品编号: DC10486
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应用领域
NCT-503磷酸甘油酸脱氢酶 (PHGDH) 抑制剂，IC50 值为2.5 µM。
| Cas No.: |
1916571-90-8 |
| 名称: |
N-(4,6-dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide |
| 别名: |
NCT 503,NCT503 |
| SMILES: |
S=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2)CC1)NC3=NC(C)=CC(C)=C3 |
| 分子式: |
C20H23F3N4S |
| 分子量: |
408.48 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM. It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors. |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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