BMS-986205(Linrodostat)
产品编号: DC10131
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应用领域
Linrodostat (BMS-986205) 是一种选择性的不可逆的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂，对 IDO1-HEK293 细胞具有有效的抑制作用，其 IC50 值为1.1 nM。Linrodostat 在晚期癌症中具有良好的药理活性。
| Cas No.: |
1923833-60-6 |
| 名称: |
(R)-N-(4-chlorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide |
| 别名: |
BMS 986205,BMS986205 |
| SMILES: |
C[C@H](C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC=C(C=C4)Cl |
| 分子式: |
C24H24ClFN2O |
| 分子量: |
410.15 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial BMS-986205 is an anticancer drug candidate. Bristol-Myers Squibb is developing an orally administered BMS 986205 for the treatment of cancer. |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
| 2018-0101 |
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