RORγt inhibitor 1
产品编号: DC11869
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应用领域
RORγt Inverse agonist 8 是一种高效、有选择性的,可口服利用的 RORγt 反向激动剂，对人 RORγt-LBD (ligand binding domain) 作用的 IC50 值为 19 nM。
| Cas No.: |
2079892-79-6 |
| 名称: |
(S)-N-(8-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-methylpyrimidine-5-carboxamide |
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| SMILES: |
C(C)1=NC=C(C(NC2=CN3C=CN=C3C(CN3CCN(C(C4CCCC4)=O)[C@H](C)C3)=C2C)=O)C=N1 |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CC |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3124_DC11869_2079892-79-6 |
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