DAPT
产品编号: DC7396
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
DAPT (GSI-IX) 是一种有效的，口服活性的 γ 分泌酶 (γ-secretase) 抑制剂，对总 amyloid-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。DAPT 抑制 Notch 1 信号传导并诱导细胞分化。DAPT 还可诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)。DAPT 具有神经保护活性，并可用于自身免疫性和淋巴增生性疾病，退化性疾病和癌症的研究。
| Cas No.: |
208255-80-5 |
| 名称: |
(S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate |
| 别名: |
GSI-IX; GSI IX |
| SMILES: |
C(OC(C)(C)C)(=O)[C@H](NC(=O)[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C)C1=CC=CC=C1 |
| 分子式: |
C23H26F2N2O4 |
| 分子量: |
432.46 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
In human primary neuronal cultures, DAPT also shows inhibitory effects on Aβ production with IC50 of 115 nM and 200 nM respectively For Aβ total and Aβ42, which is 5-10-fold lower than is observed in HEK 293 cells. A recent study shows that DAPT inhibit |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
