| Cas No.: | 2123489-30-3 |
| 名称: | (5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone |
| 别名: | WNK-IN-11; WNK IN 11; WNKIN11; WNK inhibitor 11; WNK inhibitor-11,2123489-30-3 |
| SMILES: | O=C(C1=CC(C2=CSC(NC)=N2)=NC=C1Cl)N3CCN(CC4=CC=C(Cl)C=C4)CC3 |
| 分子式: | C21H21Cl2N5Os |
| 分子量: | 462.39 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| References: | WNK inhibitor 11 is a potent, selectiive and orally active inhibitor of WNK1 kinase with IC50 of 6 nM, 1,000-fold selectivity over WNK4 and 57-fold selectivity over WNK2; shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and FER kinase; reduces blood pressure in mice overexpressing human WNK1, and induced diuresis, natriuresis and kaliuresis in spontaneously hypertensive rats. |
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| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_938_DC12501_2123489-30-3 |
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COA
| LOT NO. | DOWNLOAD |
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