| References: |
Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.
in vitro: BMS-247550 (EpoB), a novel epothilone B analogue, induces cell cycle arrest at the G(2)-M phase transition and subsequent apoptotic cell death of MDA-MB-468 (468) cells.
in vivo: Ixabepilone, on a once every 21-day schedule, is modestly active against metastatic gastric cancer previously treated with a taxane. The days 1-5 every 21 days schedule had a more favorable safety profile but no activity. The results of this study suggest that once every 21-day ixabepilone schedule should be pursued further in untreated gastric or gastroesophageal adenocarcinoma patients. Ixabepilone has demonstrated activity in patients with chemotherapy-naive metastatic HRPC. Major toxicities were neutropenia and neuropathy. Further testing to define its activity relative to standard therapy is warranted.
For the detailed information of Ixabepilone, the solubility of Ixabepilone in water, the solubility of Ixabepilone in DMSO, the solubility of Ixabepilone in PBS buffer, the animal experiment（test） (test) of Ixabepilone, the cell expriment (test) of Ixabepilone, the in vivo, in vitro and clinical trial test of Ixabepilone, the EC50, IC50,and Affinity of Ixabepilone,, please contact DC Chemicals. |
