FG2216

产品编号: DC8195 Featured
FG2216
结构式
223387-75-5
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中国地区超过5000个高品质化合物库存
应用领域
FG-2216 (IOX3; YM311) 是 HIF-PHD 抑制剂,IC50 值为 3.9 uM。
Cas No.: 223387-75-5
名称:
别名: FG2216,FG-2216,FG 2216
SMILES: C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O
分子式: C12H9ClN2O4
分子量: 280.66
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. FG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC). For the detailed information of FG2216, the solubility of FG2216 in water, the solubility of FG2216 in DMSO, the solubility of FG2216 in PBS buffer, the animal experiment (test) of FG2216, the cell expriment (test) of FG2216, the in vivo, in vitro and clinical trial test of FG2216, the EC50, IC50,and affinity,of FG2216, For the detailed information of FG2216, the solubility of FG2216 in water, the solubility of FG2216 in DMSO, the solubility of FG2216 in PBS buffer, the animal experiment (test) of FG2216, the cell expriment (test) of FG2216, the in vivo, in vitro and clinical trial test of FG2216, the EC50, IC50,and affinity,of FG2216, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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