ZK824859
产品编号: DC12039
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应用领域
ZK824859 是一种口服有效的选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，用于人 uPA，tPA 和纤溶酶，IC50 分别为 79 nM，1580 nM 和 1330 nM。
| Cas No.: |
2254001-81-3 |
| 名称: |
(R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid |
| 别名: |
ZK824859，ZK-824859，ZK 824859，2254001-81-3 |
| SMILES: |
CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O |
| 分子式: |
C23H22F2N2O4 |
| 分子量: |
428.436 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM); ZK 824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM; demonstrates efficacy in either acute or chronic mouse EAE models. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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