Cinacalcet (AMG-073)

产品编号: DC8801 Featured
Cinacalcet (AMG-073)
结构式
226256-56-0
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中国地区超过5000个高品质化合物库存
应用领域
Cinacalcet (AMG 073) 是一种可口服的 Ca receptor (CaR) 激动剂,用于治疗心血管疾病。
Cas No.: 226256-56-0
名称:
别名: AMG 073; AMG073; AMG-073
SMILES: C(N[C@H](C1=C2C(C=CC=C2)=CC=C1)C)CCC1=CC=CC(C(F)(F)F)=C1
分子式: C22H22F3N
分子量: 357.41
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Cinacalcet is the only calcimimetic approved for HPT secondary to chronic kidney disease (CDK), parathyroid carcinoma, and, in some countries, primary HPT. Clinical trials showed that cinacalcet reduced PTH and calcemia both in CDK and primary HPT, lowering the risk of bone fractures, surgery, and cardiovascular complications in the former patients. Long-term safety and pharmacoeconomics have to be fully tested yet. Few both in vitro and in vivo studies showed an association between Arg990Gly-CASR polymorphism and cinacalcet sensitivity, though in patients with severe CASR inactivating mutations the drug substantially retained its positive clinical effects.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC8801 Cinacalcet (AMG-073) Cinacalcet (AMG 073) 是一种可口服的 Ca receptor (CaR) 激动剂,用于治疗心血管疾病。
DC5083 Cinacalcet (AMG-073) HCl Cinacalcet hydrochloride (AMG-073 hydrochloride) 是一种可口服的 Ca receptor (CaR) 激动剂,用于治疗心血管疾病。