AMG-510

产品编号: DC22298 Featured
AMG-510
结构式
2296729-00-3
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中国地区超过5000个高品质化合物库存
应用领域
AMG-510 racemate 是 AMG-510 的低活性外消旋体。AMG-510 是一种有效的,口服生物可利用的,选择性的 KRAS G12C 共价抑制剂,具有抗肿瘤活性。
Cas No.: 2296729-00-3
名称: CID 137278711
别名: AMG510;Kras G12C inhibitor 9;2B2VM6UC8G;AMG 510;6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one;GTPL10678;BCP30452;s8830;DB15569;Pyrido(2,3-d)pyrimidin
SMILES: FC1=C(C2C(=C([H])C([H])=C([H])C=2O[H])F)N=C2C(=C1[H])C(=NC(N2C1=C(C([H])([H])[H])C([H])=C([H])N=C1C([H])(C([H])([H])[H])C([H])([H])[H])=O)N1C([H])([H])C([H])([H])N(C(C([H])=C([H])[H])=O)C([H])([H])[C@]1([H])C([H])([H])[H]
分子式: C30H30F2N6O3
分子量: 560.594413280487
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, thro
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_1120_DC22298_2296729-00-3
COA
LOT NO. DOWNLOAD
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