首页 > 产品 > 特色产品

AMG-510

产品编号: DC22298 Featured
AMG-510
结构式
2296729-00-3
此产品仅供科研所需，我们不出售给病人
​我们将匹配市场上最好的价格给您
Email：order@dcbio.cn
免费咨询电话：4008862077
询盘
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
AMG-510 racemate 是 AMG-510 的低活性外消旋体。AMG-510 是一种有效的，口服生物可利用的，选择性的 KRAS G12C 共价抑制剂，具有抗肿瘤活性。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 2296729-00-3
名称: CID 137278711
别名: AMG510;Kras G12C inhibitor 9;2B2VM6UC8G;AMG 510;6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one;GTPL10678;BCP30452;s8830;DB15569;Pyrido(2,3-d)pyrimidin
SMILES: FC1=C(C2C(=C([H])C([H])=C([H])C=2O[H])F)N=C2C(=C1[H])C(=NC(N2C1=C(C([H])([H])[H])C([H])=C([H])N=C1C([H])(C([H])([H])[H])C([H])([H])[H])=O)N1C([H])([H])C([H])([H])N(C(C([H])=C([H])[H])=O)C([H])([H])[C@]1([H])C([H])([H])[H]
分子式: C30H30F2N6O3
分子量: 560.594413280487
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, thro
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_1120_DC22298_2296729-00-3
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC26116 Poloppin Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays.
DC26114 GpTx-1 GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5..
DC26113 LSP4–2022 LSP4–2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.
DC26109 MCL0129 tetrahydrochloride MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
DC26100 SR-16507 SR-16507 is a potent full agonist of ORL1 receptor (NOP receptor) and partial agonist of mu-opioid receptor with Ki of 5.22 nM and 1.07 nM, respectively.
DC26091 PF-05198007 PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, no significant activity against Nav1.5 (IC50>10 uM).
DC26081 JTE-852 JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively.
DC26080 GX-674 GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.
DC26078 GNE-616 GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7).
DC26071 BMS 814580 A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
​ 免费咨询电话：4008862077
​ QQ：1026657369
​ 邮箱：order@dcbio.cn
我们所有的产品仅供研究所需，严禁用于人体和其他目的
站点地图|隐私政策Copyright © 2018-2020 All Rights Reserved. 技术支持:库价软件