TMS

产品编号: DC2080 Featured
TMS
结构式
24144-92-1
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中国地区超过5000个高品质化合物库存
应用领域
TMS 是一种选择性 CYP1B1 抑制剂。
Cas No.: 24144-92-1
名称:
别名:
SMILES: COC1=CC(=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)OC
分子式: C18H20O4
分子量: 300.35
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.1 It is 50-fold selective For the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.1 In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.2 For the detailed information about the solubility of TMS in water, the solubility of TMS in DMSO, the solubility of TMS in PBS buffer, the animal experiment(test) of TMS, the in vivo,in vitro and clinical trial test of TMS, the cell experiment(test) of TMS, the IC50, EC50 and Affinity of TMS , please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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