TAK-242 (Resatorvid)
产品编号: DC7305
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中国地区超过5000个高品质化合物库存
应用领域
Resatorvid (TAK-242) 是一种选择性的 TLR4 信号传导抑制剂。Resatorvid 抑制 NO，TNF-R 和 IL-6 的产生，其 IC50 值分别为 1.8 nM，1.9 nM，1.3 nM。Resatorvid 下调 TLR4 下游信号分子 MyD88 和 TRIF 的表达。Resatorvid 抑制自噬 (autophagy)，并在各种炎症性疾病中起关键作用。
| Cas No.: |
243984-11-4 |
| 名称: |
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| 别名: |
Resatorvid; TAK242; TAK 242 |
| SMILES: |
CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl |
| 分子式: |
C15H17ClFNO4S |
| 分子量: |
361.82 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
IC50 value: 1.1-11 nM
Target: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1679_DC7305_243984-11-4 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
