Bay 41-4109 (racemate)

产品编号: DC10085 Featured
Bay 41-4109 (racemate)
结构式
298708-79-9
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中国地区超过5000个高品质化合物库存
应用领域
BAY 41-4109 racemate是BAY 41-4109的消旋体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂,IC50值为53 nM。
Cas No.: 298708-79-9
名称:
别名: Bay41-4109 racemate; Bay-41-4109 racemate
SMILES: O=C(C1=C(C)N=C(C2=NC=C(F)C=C2F)NC1C3=CC=C(F)C=C3Cl)OC
分子式: C18H13ClF3N3O2
分子量: 395.76
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: BAY 41-4109 racemate is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. InVitro: BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition. InVivo: BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10882 JNJ-632 JNJ-632 是一种乙型肝炎病毒 (HBV) 衣壳组装调节剂 (CAM)。
DC10085 Bay 41-4109 (racemate) BAY 41-4109 racemate是BAY 41-4109的消旋体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂,IC50值为53 nM。