SB-431542
产品编号: DC5189
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应用领域
SB-431542 是一种有效，选择性的 ALK5/TGF-β type I Receptor 抑制剂，IC50 值为 94 nM。
| Cas No.: |
301836-41-9 |
| 名称: |
4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide |
| 别名: |
SB431542, SB 431542 |
| SMILES: |
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
| 分子式: |
C22H16N4O3 |
| 分子量: |
384.39 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, wi |
| Kinase Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
