Ciliobrevin A(HPI4)
产品编号: DC9875
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应用领域
Ciliobrevin A 是一种 Hedgehog (Hh) 信号通路抑制剂，平均抑制浓度 (IC50) 值小于 10 μM。
| Cas No.: |
302803-72-1 |
| 名称: |
2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile |
| 别名: |
HPI-4,HPI 4 |
| SMILES: |
C1C=C2C(N/C(/NC2=CC=1)=C(/C(C1C=CC(Cl)=CC=1Cl)=O)\C#N)=O |
| 分子式: |
C17H9Cl2N3O2 |
| 分子量: |
358.18 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
HPI-4 is a Hedgehog pathway inhibitor and ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics and HPI-4 blocks Sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM) downstream of Smo. It also inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2867_DC9875_302803-72-1 |
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COA
| LOT NO. |
DOWNLOAD |
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