STF-62247
产品编号: DC10456
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应用领域
STF-62247是一个TGN抑制剂，在RCC4 和RCC4/VHL细胞中的IC50分别是0.625 μM和16 μM。
| Cas No.: |
315702-99-9 |
| 名称: |
N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
| 别名: |
STF-62247,STF 62247,STF62247 |
| SMILES: |
Cc1cccc(c1)Nc1scc(n1)c1ccncc1 |
| 分子式: |
C15H13N3S |
| 分子量: |
267.3 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice.1,2,3 STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM). |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_224_DC10456_315702-99-9 |
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COA
| LOT NO. |
DOWNLOAD |
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