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BRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs. For the detailed information of BRD7116, the solubility of BRD7116 in water, the solubility of BRD7116 in DMSO, the solubility of BRD7116 in PBS buffer, the animal experiment (test) of BRD7116, the cell expriment (test) of BRD7116, the in vivo, in vitro and clinical trial test of BRD7116, the EC50, IC50,and affinity,of BRD7116, For the detailed information of BRD7116, the solubility of BRD7116 in water, the solubility of BRD7116 in DMSO, the solubility of BRD7116 in PBS buffer, the animal experiment (test) of BRD7116, the cell expriment (test) of BRD7116, the in vivo, in vitro and clinical trial test of BRD7116, the EC50, IC50,and affinity,of BRD7116, Please contact DC Chemicals. |
