Monastrol

产品编号: DC2082 Featured
Monastrol
结构式
329689-23-8
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中国地区超过5000个高品质化合物库存
应用领域
Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白 Eg5 的抑制剂,IC50 值为 14 μM。
Cas No.: 329689-23-8
名称:
别名:
SMILES: S=C1NC(C2=CC(O)=CC=C2)C(C(OCC)=O)=C(C)N1
分子式: C14H16N2O3S
分子量: 292.4
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM).. It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes. Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC9270 Eg5 Inhibitor III(Dimethylenastron) Dimethylenastron 是一种有效的驱动蛋白 Eg5 抑制剂,IC50 值为 200 nM。
DC2082 Monastrol Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白 Eg5 的抑制剂,IC50 值为 14 μM。