Substance P

产品编号: DC10663 Featured
Substance P
结构式
33507-63-0
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中国地区超过5000个高品质化合物库存
应用领域
Substance P (Neurokinin P) 是一种神经肽,在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor,NK1R)。
Cas No.: 33507-63-0
名称:
别名:
SMILES: [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O
分子式: C63H98N18O13S
分子量: 1347.6
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. In addition, Substance P is essential in smooth muscle contraction, pain, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells. Alternate studies suggest that Substance P is a key factor in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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