Alda-1

产品编号: DC8723 Featured
Alda-1
结构式
349438-38-6
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中国地区超过5000个高品质化合物库存
应用领域
Alda-1是有效的 ALDH2 激动剂,其激活野生型ALDH2并恢复近似野生型活性至ALDH2*2。
Cas No.: 349438-38-6
名称:
别名: ALDA1,ALDA 1
SMILES: C(NCC1C=C2C(=CC=1)OCO2)(=O)C1=C(Cl)C=CC=C1Cl
分子式: C15H11Cl2NO3
分子量: 324.16
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). in vitro: ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding. Alda-1 activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2. in vivo: Alda-1 inhibits atherosclerosis and attenuates NAFLD in apoE-/- mice. The treatment with Alda-1 results in a significant decrease of TG level in liver of apoE-/- mice.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_2461_DC8723_349438-38-6
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC8723 Alda-1 Alda-1是有效的 ALDH2 激动剂,其激活野生型ALDH2并恢复近似野生型活性至ALDH2*2。