PYR 41
产品编号: DC7257
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应用领域
PYR-41 是一种选择性，可透过细胞的泛素活化酶 E1 抑制剂，IC50 值小于10 μM，对E2和E3基本无作用。
| Cas No.: |
418805-02-4 |
| 名称: |
Benzoicacid,4-[4-[(5-nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]-,ethylester |
| 别名: |
PYR41; PYR-41 |
| SMILES: |
CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2 |
| 分子式: |
C17H13N3O7 |
| 分子量: |
371.3 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
PYR-41 (50 μM) inhibits activity of ubiquitin-activating enzyme E1 by over 90%. PYR-41 could be a target For nucleophilic attack and potentially reacts with the active site cysteine of E1. PYR-41 efficiently blocks cyclin E degradation. PYR-41 decreases |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
