C188-9

产品编号: DC10864 Featured
C188-9
结构式
432001-19-9
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中国地区超过5000个高品质化合物库存
应用领域
C188-9 是 Stat3 的抑制剂,其 Kd 值为 4.7 nM。
Cas No.: 432001-19-9
名称: N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide
别名: C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084
SMILES: O=S(C1=CC=C(OC)C=C1)(NC2=C3C=CC=CC3=C(O)C(C4=C5C=CC=CC5=CC=C4O)=C2)=O
分子式: C27H21NO5S
分子量: 471.114
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10864 C188-9 C188-9 是 Stat3 的抑制剂,其 Kd 值为 4.7 nM。