BMS-536924
产品编号: DC5037
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应用领域
BMS-536924 是一种具有口服活性，竞争性和选择性的胰岛素样生长因子受体 (IGF-1R) 激酶和胰岛素受体 (IR) 抑制剂，IC50 分别为 100 nM 和 73 nM。BMS-536924 具有抗癌活性。
| Cas No.: |
468740-43-4 |
| 名称: |
(S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one |
| 别名: |
BMS 536924,BMS536924 |
| SMILES: |
CC1=CC(=CC2=C1N/C(=C\3/C(=CC=NC3=O)NC[C@H](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5 |
| 分子式: |
C25H26ClN5O3 |
| 分子量: |
479.96 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.
IC50 value: 100 nM (IGF-1R); 73 nM (IR)
Target: IGF-1R; IR
in vitro: BMS-536924 also inhibits FAK and Lck with IC50 of 150 nM and 341 nM, respectively. BMS-536924 inhibits ce |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
