MK0752
产品编号: DC7666
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应用领域
MK-0752是γ-secretase抑制剂，能减少Aβ40的产生，IC50为5 nM。
| Cas No.: |
471905-41-6 |
| 名称: |
3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid |
| 别名: |
MK-0752,MK 0752 |
| SMILES: |
C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl |
| 分子式: |
C21H21ClF2O4S |
| 分子量: |
442.9 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear tr |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1886_DC7666_471905-41-6 |
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COA
| LOT NO. |
DOWNLOAD |
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