NVP-ADW742
产品编号: DC7549
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应用领域
NVP-ADW742 (ADW742) 是一种具有口服活性，选择性的 IGF-1R 酪氨酸激酶抑制剂，IC50 为 0.17 μM。NVP-ADW742 抑制胰岛素受体 (InsR)，IC50 为 2.8 μM。NVP-ADW742 在肿瘤细胞中诱导多效性抗增殖/促凋亡 (apoptosis)。
| Cas No.: |
475488-23-4 |
| 名称: |
5-(3-(benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| 别名: |
ADW742 |
| SMILES: |
C1=NC(N)=C2C(C3=CC=CC(OCC4=CC=CC=C4)=C3)=CN([C@H]3C[C@H](CN4CCCC4)C3)C2=N1 |
| 分子式: |
C28H31N5O |
| 分子量: |
453.58 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
NVP-ADW742 exhibits a 6-fold greater selectivity For IGF-1R versus InsR with IC50 of 2.8 μM; minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210 with IC50 greater than 5 μM. NVP-ADW742 significantly inhibits the serum-stimulat |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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