JNJ-10229570
产品编号: DC12374
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应用领域
JNJ-10229570 是肾上腺皮质受体 1 (MC1R) 和肾上腺皮质受体 5 (MC5R) 的拮抗剂，可抑制皮脂腺分化和皮质特异性脂质的产生，其抑制 125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的 IC50 值分别为 270 nM 和 200 nM。
| Cas No.: |
524923-88-4 |
| 名称: |
Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)- |
| 别名: |
JNJ-10229570; JNJ10229570; JNJ 10229570 |
| SMILES: |
COC1=CC=CC=C1C2=N/C(SN2C3=CC=CC=C3OC)=N\C4=CC=CC=C |
| 分子式: |
C22H19N3O2S |
| 分子量: |
389.47 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_906_DC12374_524923-88-4 |
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| LOT NO. |
DOWNLOAD |
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