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In Vitro: Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity.In vivo:The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.For the detailed information of Diphemanil Methylsulfate, the solubility of Diphemanil Methylsulfate in water, the solubility of Diphemanil Methylsulfate in DMSO, the solubility of Diphemanil Methylsulfate in PBS buffer, the animal experiment (test) of Diphemanil Methylsulfate, the cell expriment (test) of Diphemanil Methylsulfate, the in vivo, in vitro and clinical trial test of Diphemanil Methylsulfate, the EC50, IC50,and Affinity of Diphemanil Methylsulfate, Please contact DC Chemicals. |
