Brivanib (bms-540215)

产品编号: DC2019 Featured
Brivanib (bms-540215)
结构式
649735-46-6
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中国地区超过5000个高品质化合物库存
应用领域
Brivanib 是一种ATP竞争性的 VEGFR2 抑制剂,IC50 值为 25 nM;可以适度抑制 VEGFR-1 和 FGFR-1,对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。
Cas No.: 649735-46-6
名称: (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol
别名: bms540215, bms 540215
SMILES: C(OC1=CN2C(=C1C)C(OC1C=CC3=C(C=1F)C=C(C)N3)=NC=N2)C(O)C
分子式: C19H19FN4O3
分子量: 370.38
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Brivanib is the hydrolyzed Form of Brivanib alaninate, which is a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Brivanib (bms-540215) in water, the solubility of Brivanib (bms-540215) in DMSO, the solubility of Brivanib (bms-540215) in PBS buffer, the animal experiment(test) of Brivanib (bms-540215),the in vivo,in vitro and clinical trial test of Brivanib (bms-540215),the cell experiment(test) of Brivanib (bms-540215),the IC50, EC50 and Affinity of Brivanib (bms-540215), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC2019 Brivanib (bms-540215) Brivanib 是一种ATP竞争性的 VEGFR2 抑制剂,IC50 值为 25 nM;可以适度抑制 VEGFR-1 和 FGFR-1,对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。