Regorafenib (BAY73-4506,Fluoro-Sorafenib)

产品编号: DC1030 Featured
Regorafenib (BAY73-4506,Fluoro-Sorafenib)
结构式
755037-03-7
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中国地区超过5000个高品质化合物库存
应用领域
Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂,抑制VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 的 IC50 分别为13/4.2/46,22,7,1.5 和2.5 nM。
Cas No.: 755037-03-7
名称: 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
别名: Regorafenib, BAY 73-4506, Sorafenib, BAY-73-4506, BAY 73 4506
SMILES: N(C1=CC=C(Cl)C(C(F)(F)F)=C1)C(NC1=CC=C(OC2C=CN=C(C(=O)NC)C=2)C=C1F)=O
分子式: C21H15ClF4N4O3
分子量: 482.82
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Regorafenib is an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Regorafenib (BAY 73-4506, Fluoro-Sorafenib) in water, the solubility of Regorafenib (BAY 73-4506, Fluoro-Sorafenib) in DMSO, the solubility of Regorafenib (BAY 73-4506, Fluoro-Sorafenib) in PBS buffer, the animal experiment(test) of Regorafenib (BAY 73-4506, Fluoro-Sorafenib),the in vivo,in vitro and clinical trial test of Regorafenib (BAY 73-4506, Fluoro-Sorafenib),the cell experiment(test) of Regorafenib (BAY 73-4506, Fluoro-Sorafenib),the IC50, EC50 and Affinity of Regorafenib (BAY 73-4506, Fluoro-Sorafenib), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC9777 Regorafenib monohydrate(BAY 73-4506) Regorafenib monohydrate 是一种多靶点抑制剂,对VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 的 IC50 分别为 13 nM,4.2 nM,46 nM,22 nM,7 nM,1.5 nM 和 2.5 nM。
DC7902 Fruquintinib (HMPL-013) Fruquintinib (HMPL-013) 是有效,选择性的 VEGFR 1/2/3 抑制剂,IC50 值分别为33,0.5,and 35 nM。
DC1030 Regorafenib (BAY73-4506,Fluoro-Sorafenib) Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂,抑制VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 的 IC50 分别为13/4.2/46,22,7,1.5 和2.5 nM。