Bi 2536
产品编号: DC7083
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应用领域
BI 2536 是 PLK1 和 BRD4 的双抑制剂，IC50 分别为 0.83 和 25 nM。BI-2536 抑制 IFNB (IFN-β，干扰素 β) 基因转录。
| Cas No.: |
755038-02-9 |
| 名称: |
(R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide |
| 别名: |
BI-2536; BI2536 |
| SMILES: |
C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@@H](CC)C(=O)N3C)C(OC)=C1 |
| 分子式: |
C28H39N7O3 |
| 分子量: |
521.66 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of A |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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