NVP-TAE684
产品编号: DC7303
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应用领域
NVP-TAE 684 (TAE 684) 是一种高效的，选择性的 ALK 抑制剂，阻止 ALCL 衍生的 ALK 依赖性细胞株的生长，IC50 值为 2-10 nM。
| Cas No.: |
761439-42-3 |
| 名称: |
5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine |
| 别名: |
TAE684; NVP TAE684 |
| SMILES: |
CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
| 分子式: |
C30H40ClN7O3S |
| 分子量: |
614.2 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
TAE684 does not exhibit significant cross-reactivity against other kinases. TAE684 potently inhibits the proliferation of Ba/F3 NPM-ALK cells with IC50 of 3 nM, without affecting the survival of Ba/F3 cells even at 1 μM. TAE684 also inhibits proliferation |
| Kinase Assay: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1678_DC7303_761439-42-3 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
