Masitinib
产品编号: DC7460
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
Masitinib (AB1010) 是一种有效的，生物口服可利用的，且选择性的 c-Kit 抑制剂 (对于人重组c-Kit，IC50 =200 nM)，它还抑制 PDGFRα/β (IC50s=540/800 nM)，Lyn (对 LynB 的IC50=510 nM)，Lck，较小程度上抑制 FGFR3 和 FAK。Masitinib (AB1010) 有抗增殖，促凋亡活性，且毒性低。
| Cas No.: |
790299-79-5 |
| 名称: |
N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide |
| 别名: |
AB1010; AB-1010; AB 1010 |
| SMILES: |
CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5 |
| 分子式: |
C28H30N6Os |
| 分子量: |
498.64 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
Masitinib is a competitive inhibitor against ATP at concentrations ≤500 nM. Masitinib also potently inhibits recombinant PDGFR and the intracellular kinase Lyn, and to a lesser extent, fibroblast growth factor receptor 3. In contrast, Masitinib demonstrat |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
