GSK180736A
产品编号: DC10124
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应用领域
GSK180736A 是G蛋白偶联受体激酶2 (GRK2)的抑制剂，IC50值为0.77 μM。
| Cas No.: |
817194-38-0 |
| 名称: |
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| 别名: |
GSK180736A,GSK-180736A,GSK180736A |
| SMILES: |
CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4 |
| 分子式: |
C19H16FN5O2 |
| 分子量: |
365.36 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
In Vitro: GSK180736A is a compound structurally similar to paroxetine that is developed as a ROCK inhibitor, is shown to be an even more potent and selective inhibitor of GRK2 with an IC50 of 0.77 μM and more than 100-fold selectivity over other GRKs. ROCK1 is a potential therapeutic target in the treatment of cardiovascular diseases such as hypertension. GSK180736A is a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50=100 nM). |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_107_DC10124_817194-38-0 |
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COA
| LOT NO. |
DOWNLOAD |
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