GLX351322

产品编号: DC11009 Featured
GLX351322
结构式
835598-94-2
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中国地区超过5000个高品质化合物库存
应用领域
GLX351322 是一种 NADPH 氧化酶 4 (Nox4) 抑制剂,在 NOX4 过表达的细胞中,抑制过氧化氢的产生,IC50 值为 5 μM。
Cas No.: 835598-94-2
名称: Ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-5,6-dihydro-4H-cyclopenta-[b]thiophene-3-carboxylate
别名: GLX 351322;GLX-351322
SMILES: O=C(OCC)C1=C(SC2=C1CCC2)NC(CN3CCN(CC3)C(C4=CC=CO4)=O)=O
分子式: C21H25N3O5S
分子量: 431.507
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM; dispplays an order of magnitude less activity against NOX2; counteracts non-fasting hyperglycemia and impairs glucose tolerance in HFD-treated male C57BL/6 mice, prevents high-glucose-induced human islet cell reactive oxygen species (ROS) production and death.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC11009 GLX351322 GLX351322 是一种 NADPH 氧化酶 4 (Nox4) 抑制剂,在 NOX4 过表达的细胞中,抑制过氧化氢的产生,IC50 值为 5 μM。
DC10841 VAS 2870 VAS2870是NADPH氧化酶 (NADPH oxidase (NOX)) 抑制剂。