ATH686
产品编号: DC10921
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应用领域
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.
| Cas No.: |
853299-52-2 |
| 名称: |
1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea |
| 别名: |
ATH 686;ATH-686 |
| SMILES: |
N(C1=CC=C(OC2C=CN=C(N)N=2)C=C1)C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)=O |
| 分子式: |
C25H28F3N7O2 |
| 分子量: |
515.541 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase; selectively kills leukemic cells harboring mutant FLT3 with no apparent effect on cells harboring wild-type FLT3, via inhibition of FLT3 kinase activity; potently inhibits cell proliferation of FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells (IC50<1 nM), via induction of apoptosis. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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