wp1066(STAT Inhibitor III)

产品编号: DC8244 Featured
wp1066(STAT Inhibitor III)
结构式
857064-38-1
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中国地区超过5000个高品质化合物库存
应用领域
WP1066 是一种新颖的 JAK2 和 STAT3 抑制剂,对 STAT5 和 ERK1/2 也起作用,但对 JAK1 和 JAK3 没有影响。
Cas No.: 857064-38-1
名称: 3-​(6-​bromo-​2-​pyridinyl)-​2-​cyano-​N-​[(1S)-​1-​phenylethyl]-​2E-​propenamide
别名: wp1066, wp 1066,wp-1066
SMILES: C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
分子式: C17H14BrN3O
分子量: 356.2
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 µM.1 It also induces apoptosis in U87-MG (IC50 = 5.6 µM) and U373-MG (IC50 = 3.7 µM) cells.WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats. For the detailed information of wp1066(STAT Inhibitor III), the solubility of wp1066(STAT Inhibitor III) in water, the solubility of wp1066(STAT Inhibitor III) in DMSO, the solubility of wp1066(STAT Inhibitor III) in PBS buffer, the animal experiment (test) of wp1066(STAT Inhibitor III), the cell expriment (test) of wp1066(STAT Inhibitor III), the in vivo, in vitro and clinical trial test of wp1066(STAT Inhibitor III), the EC50, IC50,and affinity,of wp1066(STAT Inhibitor III), For the detailed information of wp1066(STAT Inhibitor III), the solubility of wp1066(STAT Inhibitor III) in water, the solubility of wp1066(STAT Inhibitor III) in DMSO, the solubility of wp1066(STAT Inhibitor III) in PBS buffer, the animal experiment (test) of wp1066(STAT Inhibitor III), the cell expriment (test) of wp1066(STAT Inhibitor III), the in vivo, in vitro and clinical trial test of wp1066(STAT Inhibitor III), the EC50, IC50,and affinity,of wp1066(STAT Inhibitor III), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_2220_DC8244_857064-38-1
COA
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