Quarfloxin (CX-3543)
产品编号: DC7664
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应用领域
Quarfloxin (CX-3543) 是一种具有抗肿瘤活性的氟喹诺酮类衍生物，其靶向抑制RNA pol I的活性，在神经母细胞瘤中的IC50 值在纳摩尔级别。Quarfloxin 干扰核糖体DNA中核蛋白与G-四重DNA结构的相互作用。
| Cas No.: |
865311-47-3 |
| 名称: |
5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide. |
| 别名: |
CX 3543; Quarfloxacin; CX3543; CX-3543 |
| SMILES: |
[H][C@]1(C2=NC=CN=C2)CN(C3=C(F)C=C4C5=C3OC6=C(C=C(C=CC=C7)C7=C6)N5C=C(C(NCC[C@]8([H])CCCN8C)=O)C4=O)CC1 |
| 分子式: |
C35H33FN6O3 |
| 分子量: |
604.67 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction For rRNA bi |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1885_DC7664_865311-47-3 |
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COA
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DOWNLOAD |
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