JNJ-26854165 (Serdemetan)
产品编号: DC7175
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应用领域
Serdemetan(JNJ-26854165)是HDM2泛素连接酶拮抗剂，能诱导p53野生型细胞的早期凋亡。
| Cas No.: |
881202-45-5 |
| 名称: |
N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine |
| 别名: |
JNJ 26854165; JNJ26854165; JNJ-26854165 |
| SMILES: |
C(NCCC1C2=C(NC=1)C=CC=C2)1=CC=C(NC2C=CN=CC=2)C=C1 |
| 分子式: |
C21H20N4 |
| 分子量: |
328.41 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
JNJ 26854165 is a novel tryptamine derivative which activates p53 and acts as a HDM2 ubiquitin ligase antagonist. JNJ 26854165 inhibits cell growth and induces apoptosis in leukemia cell lines with IC50 values of 0.24, 0.33, 0.32 and 0.44 μM at 72 hours |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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