Evofosfamide(TH-302)
产品编号: DC7689
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应用领域
Evofosfamide (TH-302) 是一种缺氧 (hypoxia) 激活前药，缺氧 (N2) 和常氧 (21% O2) 环境下，IC50 分别为 10 μM 和 1000 μM。
| Cas No.: |
918633-87-1 |
| 名称: |
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| 别名: |
TH 302; TH302 |
| SMILES: |
CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr |
| 分子式: |
C9H16Br2N5O4P |
| 分子量: |
449.04 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1904_DC7689_918633-87-1 |
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COA
| LOT NO. |
DOWNLOAD |
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