Ezutromid
产品编号: DC9821
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应用领域
Ezutromid是一个小分子utrophin的调制剂。
| Cas No.: |
945531-77-1 |
| 名称: |
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| 别名: |
SMT C1100; VOX C1100; BMN 195; SMT-C1100; VOX-C1100; BMN-195; BMN195 |
| SMILES: |
O=S(C1=CC=C(OC(C2=CC=C3C=CC=CC3=C2)=N4)C4=C1)(CC)=O |
| 分子式: |
C19H15NO3S |
| 分子量: |
337.39 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .
In vitro: 1) SMT C1100 induces increased levels of utrophin RNA in human muscle cells.
2) Treatment of human DMD cells with SMT C1100 lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment.
3) SMT C1100 wassafe and well tolerated with plasma concentrations achieved suf?cient to cause a 50% increase in concentrations of utrophin in cells.
4) SMT C1100 led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level .
In vivo: 1)The reference for administration is 50 mg/kg.
2) it was considered that no toxicity was determined for SMT C1100 administered by oral gavage to the mouse up to dose levels of 2000 mg/kg/day for 28 days. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
| 2018-0101 |
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