TB5

产品编号: DC9996 Featured
TB5
结构式
948841-07-4
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中国地区超过5000个高品质化合物库存
应用领域
TB5 是具有有效性,选择性和可逆性的 hMAO-B 抑制剂,Ki 值为 0.11±0.01 μM。
Cas No.: 948841-07-4
名称:
别名: TB-5,TB 5
SMILES: CN(C)C1=CC=C(C=C1)/C=C/C(=O)C2=CC=C(S2)Br
分子式: C15H14BrNOs
分子量: 336.25
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: TB5 is a potent, selective and reversible inhibitor of hMAO-B with a Ki value of 0.11±0.01 μM. InVitro: TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01 μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC9996 TB5 TB5 是具有有效性,选择性和可逆性的 hMAO-B 抑制剂,Ki 值为 0.11±0.01 μM。
DC9686 Ro 41-1049 hydrochloride N-(2-氨基乙基)-5-(3-氟苯基)噻唑-4-羧酰胺