NS11394

产品编号: DC8083 Featured
NS11394
结构式
951650-22-9
此产品仅供科研所需,我们不出售给病人
​我们将匹配市场上最好的价格给您
Email:order@dcbio.cn
免费咨询电话:4008862077
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
NS11394是GABA(A)受体高效调节剂,对alpha(5)亚类活性最高。
Cas No.: 951650-22-9
名称: 3'-(5-(2-hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-2-carbonitrile
别名: NS 11394,NS-11394,NS11394
SMILES: CC(C)(C1=CC2=C(C=C1)N(C=N2)C3=CC=CC(=C3)C4=CC=CC=C4C#N)O
分子式: C23H19N3O
分子量: 353.42
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Oral administration of NS11394 (1-30 mg/kg) to rats attenuated spontaneous nociceptive behaviors in response to hindpaw injection of formalin and capsaicin, effects that were blocked by the benzodiazepine site antagonist flumazenil. Ongoing inflammatory nociception, observed as hindpaw weight-bearing deficits after Freund's adjuvant injection, was also completely reversed by NS11394. Likewise, hindpaw mechanical allodynia was fully reversed by NS11394 in two rat models of peripheral neuropathic pain. Importantly, NS11394-mediated antinociception occurred at doses 20 to 40-fold lower than those inducing minor sedative or ataxic impairments. In contrast, putative antinociception associated with administration of either diazepam, zolpidem, or gaboxadol only occurred at doses producing intolerable side effects, whereas bretazenil was completely inactive despite minor influences on motoric function. In electrophysiological studies, NS11394 selectively attenuated spinal nociceptive reflexes and C-fiber-mediated wind-up in vitro pointing to involvement of a spinal site of action. The robust therapeutic window seen with NS11394 in animals suggests that compounds with this in vitro selectivity profile could have potential benefit in clinical treatment of pain in humans. For the detailed information of NS11394, the solubility of NS11394 in water, the solubility of NS11394 in DMSO, the solubility of NS11394 in PBS buffer, the animal experiment (test) of NS11394, the cell expriment (test) of NS11394, the in vivo, in vitro and clinical trial test of NS11394, the EC50, IC50,and affinity,of NS11394, For the detailed information of NS11394, the solubility of NS11394 in water, the solubility of NS11394 in DMSO, the solubility of NS11394 in PBS buffer, the animal experiment (test) of NS11394, the cell expriment (test) of NS11394, the in vivo, in vitro and clinical trial test of NS11394, the EC50, IC50,and affinity,of NS11394, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC9958 U 93631 U93631是一种高效的GABAA受体的配体,其IC50为100 nM,由GABA通过重组GABAA受体诱导产生全细胞Cl流,这种效果会被U93961迅速抑制,并且这种抑制作用是随着时间衰减的。
DC9764 Afoxolaner Afoxolaner 是一种具有口服活性的,对犬肩蜥的异恶唑啉杀虫剂/杀螨剂。Afoxolaner 作用于昆虫的 γ-氨基丁酸受体 (GABA) 和谷氨酸受体 (glutamate receptors),抑制 GABA 和谷氨酸调节的氯离子 (chloride ions) 吸收,导致过度的神经元刺激和节肢动物死亡。
DC8896 Tiagabine hydrochloride Tiagabine hydrochloride 是一种有效、选择性的 GABA reuptake 抑制剂,为抗惊厥剂;在突触体、神经元和神经胶质中,能够抑制 [3H]GABA 的重摄取,IC50 值分别为 67,446 和 182 nM。
DC8099 Saclofen β-(氨基甲基)-4 氯代苯乙烷磺酸,
DC8083 NS11394 NS11394是GABA(A)受体高效调节剂,对alpha(5)亚类活性最高。
DC11267 ONO-8590580 ONO-8590580 是 GABAA α5 的负变构调节剂。
DC10843 CGP 52432 CGP52432 是一种 GABAB 受体拮抗剂,IC50 值为 85 nM。
DC10651 SSD-114 SSD-114是一种新型 GABAB 受体正变构调节剂。
DC10625 (+)-Bicuculline (+)-Bicuculline 是对光敏感的GABA-A 受体竞争型拮抗剂。
DC10578 rac BHFF Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo.