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Gemcitabine HCl (Gemzar,LY188011)

产品编号: DC2107 Featured
Gemcitabine HCl (Gemzar,LY188011)
结构式
122111-03-9
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中国地区超过5000个高品质化合物库存
应用领域
Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor ,showed potent activity against COVID-19(SARS-COV-2) with EC50 MERS-COV(1.216), SARS-COV(4.957).
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 122111-03-9
名称: 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
别名: LY-188011
SMILES: C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
分子式: C9H11F2N3O4.HCI
分子量: 299.66
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Gemcitabine hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available For DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Gemcitabine HCl (Gemzar, LY188011) in water, the solubility of Gemcitabine HCl (Gemzar, LY188011) in DMSO, the solubility of Gemcitabine HCl (Gemzar, LY188011) in PBS buffer, the animal experiment（test） of Gemcitabine HCl (Gemzar, LY188011),the in vivo,in vitro and clinical trial test of Gemcitabine HCl (Gemzar, LY188011),the cell experiment（test） of Gemcitabine HCl (Gemzar, LY188011),the IC50, EC50 and Affinity of Gemcitabine HCl (Gemzar, LY188011), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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