Capmatinib(INCB28060)
产品编号: DC7167
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应用领域
Capmatinib (INC280; INCB28060) 是一种有效的，口服活性的，选择性的，ATP 竞争性的 c-Met 激酶抑制剂 (IC50=0.13 nM)。Capmatinib (INC280; INCB28060) 有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移，并有效诱导细胞凋亡。抗肿瘤活性。
| Cas No.: |
1029712-80-8 |
| 名称: |
2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide |
| 别名: |
INCB 28060; INCB-28060; INC280 |
| SMILES: |
CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F |
| 分子式: |
C23H17FN6O |
| 分子量: |
412.42 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
INCB28060 exhibits picomolar enzymatic potency and is highly specific For c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB2 |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1597_DC7167_1029712-80-8 |
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COA
| LOT NO. |
DOWNLOAD |
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